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Organoids and Engineered Organ Systems - 2018
The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes
Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to study esophageal epithelial homeostasis under physiological and pathologic conditions.Microfabricated Crypt Scaffolds: A New Foundation for Evaluating Human Colon Stem Cells
The emergence of 3-dimensional organoid technology has significantly advanced the understanding of epithelial stem cell biology within the past decade. Stem cells of the gastrointestinal tract have served as a template for this technology, with initial propagation of mouse intestinal enteroids and colonoids (derived from adult small intestine or colon crypt units, respectively) and subsequent adaptation of these protocols for human tissue.1–4 As such, researchers may now evaluate basic intestinal and/or colonic stem cell properties directly from patient tissue.
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