Login to your account
Don’t have an account?
Create a Free Account
Organoids and Engineered Organ Systems - 2018
The Next MacGyver: A Platform to Study Intestinal Organoids Using High-Throughput Computer-Driven Microinjection
The complex microbial community that lives in the colon plays an important role in diverse biological pathways and is linked to many diseases including inflammatory bowel disease, obesity, and cancer. Defining how microbial interactions influence host cellular molecular pathways is crucial for exploring the potential therapeutic benefits of manipulating microbial communities to treat intestinal disorders. In 2009, pioneering work in the gastrointestinal field led to the development of intestinal organoid cultures, either derived from pluripotent embryonic or reprogrammed somatic stem cells,1 or from adult stem cells derived directly from intestinal tissue or biopsy specimens.Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases
New models to study the intestine are key to understanding intestinal diseases and developing novel treatments. Intestinal organ-like culture systems (organoids and enteroids) have substantially advanced the study of the human gastrointestinal tract. Stem cell–derived cultures produce self-organizing structures that contain the multiple differentiated intestinal epithelial cell types including enterocytes, goblet, Paneth, and enteroendocrine cells. Understanding host–microbial interactions is one area in which these cultures are expediting major advancements.
The content on this site is intended for healthcare professionals.
Copyright © 2023 Elsevier Inc. except certain content provided by third parties.
