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Organoids and Engineered Organ Systems - 2018

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Editorial
Open Access
Mapping the Duodenal Crypt-Villus Transport Axis
Cellular and Molecular Gastroenterology and Hepatology
Vol. 5Issue 4p642–644Published online: March 22, 2018
- Kim E. Barrett
Cited in Scopus: 1
The epithelial cells that line the intestines have a physiological imperative to absorb nutrients while forming a semipermeable barrier that prevents the incursion of undesirable luminal solutes.¹ They also both absorb and secrete electrolytes to drive the accompanying passive transfer of water, thereby maintaining appropriate levels of luminal fluidity to support the processes of digestion and absorption. It has been estimated that the gut is presented with 8–9 L of fluid per day, with only the minority coming from oral intake of food and beverages—the remainder derives from the various intestinal secretions that mediate digestive and other functions.