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Organoids and Engineered Organ Systems - 2018

1 Results

Original Research
Open Access
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers
Cellular and Molecular Gastroenterology and Hepatology
Vol. 5Issue 4p591–609Published online: February 9, 2018
- Jianyi Yin
- Chung-Ming Tse
- Leela Rani Avula
- Varsha Singh
- Jennifer Foulke-Abel
- Hugo R. de Jonge
- and others
Cited in Scopus: 28
Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl^- and HCO₃^- secretion to total cyclic adenosine monophosphate (cAMP)-stimulated electrogenic anion secretion in human duodenal enteroid monolayers and the relevant changes after differentiation.