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Organoids and Engineered Organ Systems - 2018

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Original Research
Open Access
Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 1p73–91Published online: September 14, 2018
- Takashi Kijima
- Hiroshi Nakagawa
- Masataka Shimonosono
- Prasanna M. Chandramouleeswaran
- Takeo Hara
- Varun Sahu
- and others
Cited in Scopus: 74
Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo. We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas.