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Organoids and Engineered Organ Systems - 2018

1 Results

Original Research
Open Access
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC)
Cellular and Molecular Gastroenterology and Hepatology
Vol. 5Issue 4p549–568Published online: February 4, 2018
- Stefania Senger
- Laura Ingano
- Rachel Freire
- Antony Anselmo
- Weishu Zhu
- Ruslan Sadreyev
- and others
Cited in Scopus: 42
Untreated necrotizing enterocolitis (NEC) can lead to massive inflammation resulting in intestinal necrosis with a high mortality rate in preterm infants. Limited access to human samples and relevant experimental models have hampered progress in NEC pathogenesis. Earlier evidence has suggested that bacterial colonization of an immature and developing intestine can lead to an abnormally high inflammatory response to bacterial bioproducts. The aim of our study was to use human fetal organoids to gain insights into NEC pathogenesis.