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Mechanisms of Metabolic Syndrome

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Original Research
Open Access
Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 4p763–781Published online: March 1, 2019
- Xiaoyang Zhang
- Jun Zhang
- Haoran Sun
- Xueling Liu
- Yue Zheng
- Dan Xu
- and others
Cited in Scopus: 17
Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), yet not all obese patients develop NAFLD. The underlying causes for this discrepancy remain elusive. LPGAT1 is an acyltransferase that catalyzes the remodeling of phosphatidylglycerol (PG), a mitochondrial phospholipid implicated in various metabolic diseases. Here, we investigated the role of LPGAT1 in regulating the onset of diet-induced obesity and its related hepatosteatosis because polymorphisms of the LPGAT1 gene promoter were strongly associated with susceptibility to obesity in Pima Indians.