Skip to Main Content

Basic and Translational Advances in Liver Research

1 Results

Original Research
Open Access
Short-Term Circadian Disruption Impairs Bile Acid and Lipid Homeostasis in Mice
Cellular and Molecular Gastroenterology and Hepatology
Vol. 1Issue 6p664–677Published online: August 20, 2015
- Jessica M. Ferrell
- John Y.L. Chiang
Cited in Scopus: 48
Bile acids are physiologic detergents that also activate nuclear receptors to regulate glucose and lipid homeostasis. Cholesterol 7α-hydroxylase (Cyp7a1), the rate-limiting enzyme that converts cholesterol to bile acids, is transcriptionally regulated by bile acids and circadian rhythms. Fasting, nutrients, and the circadian clock critically control hepatic bile acid and lipid homeostasis, and circadian misalignment is associated with the metabolic syndrome in humans. To delineate these interactions, we employed a sleep disruption model to induce circadian disruption and examined hepatic metabolism with respect to bile acids, lipids, and clock gene expression.