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Basic and Translational Advances in Liver Research

1 Results

Original Research
Open Access
Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 5p685–700Published online: May 27, 2016
- Wei-Yang Chen
- Jingwen Zhang
- Smita Ghare
- Shirish Barve
- Craig McClain
- Swati Joshi-Barve
Cited in Scopus: 36
Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality, with no Food and Drug Administration–approved therapy. Chronic alcohol consumption causes a pro-oxidant environment and increases hepatic lipid peroxidation, with acrolein being the most reactive/toxic by-product. This study investigated the pathogenic role of acrolein in hepatic endoplasmic reticulum (ER) stress, steatosis, and injury in experimental ALD, and tested acrolein elimination/scavenging (using hydralazine) as a potential therapy in ALD.