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Cellular and Molecular Gastroenterology and Hepatology
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Basic and Translational Advances in Liver Research

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  • Original Research
    Open Access

    Increased Mitochondrial Genetic Diversity in Persons Infected With Hepatitis C Virus

    Cellular and Molecular Gastroenterology and Hepatology
    Vol. 2Issue 5p676–684Published online: May 27, 2016
    • David S. Campo
    • Ha-Jung Roh
    • Brian L. Pearlman
    • Daniel S. Fierer
    • Sumathi Ramachandran
    • Gilberto Vaughan
    • and others
    Cited in Scopus: 6
      The host genetic environment contributes significantly to the outcomes of hepatitis C virus (HCV) infection and therapy response, but little is known about any effects of HCV infection on the host beyond any changes related to adaptive immune responses. HCV persistence is associated strongly with mitochondrial dysfunction, with liver mitochondrial DNA (mtDNA) genetic diversity linked to disease progression.
      Increased Mitochondrial Genetic Diversity in Persons Infected With Hepatitis C Virus

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