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Basic and Translational Advances in Intestinal and Pancreatic Disease

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Original Research
Open Access
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 4p499–518Published online: March 16, 2016
- Barbara Ulmasov
- Brent A. Neuschwander-Tetri
- Jinping Lai
- Vladimir Monastyrskiy
- Trisha Bhat
- Matthew P. Yates
- and others
Cited in Scopus: 24
Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably by interacting with the Arg-Gly-Asp (RGD) sequence of the TGFB latency-associated peptide, which frees TGFB to bind its cellular receptors. However, little is known about the role of integrins in the development of CP. We investigated the effects of small-molecule integrin inhibitors in a mouse model of CP.