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Basic and Translational Advances in Intestinal and Pancreatic Disease

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Brief Report
Open Access
Contribution of Mesenteric Lymph Nodes and GALT to the Intestinal Foxp3+ Regulatory T-Cell Compartment
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 3p274–280.e3Published online: January 8, 2016
- Duke Geem
- Vu Ngo
- Akihito Harusato
- Benoit Chassaing
- Andrew T. Gewirtz
- Rodney D. Newberry
- and others
Cited in Scopus: 8
Foxp3+ regulatory T cells (Tregs) in the intestine promote immune tolerance to enteric antigens. Previous studies have shown that C-C chemokine receptor 7 (CCR7)-dependent migration of intestinal dendritic cells to the mesenteric lymph nodes (mLN) is involved in peripheral Foxp3+ Treg accumulation in the intestine and the establishment of oral tolerance. However, the relative contribution of this CCR7+ dendritic cell–mLN–Treg axis to the total intestinal Foxp3+ Treg pool during the steady-state remains unclear.