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Basic and Translational Advances in Intestinal and Pancreatic Disease

2 Results

Original Research
Open Access
Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 3p328–339Published online: January 8, 2016
- Mallappa Anitha
- François Reichardt
- Sahar Tabatabavakili
- Behtash Ghazi Nezami
- Benoit Chassaing
- Simon Mwangi
- and others
Cited in Scopus: 75
High-fat diet (HFD) feeding is associated with gastrointestinal motility disorders. We recently reported delayed colonic motility in mice fed a HFD for 11 weeks. In this study, we investigated the contributing role of gut microbiota in HFD-induced gut dysmotility.
Editorial
Open Access
Macrophages: The Missing Link in Diabetic Gastroparesis?
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 1p5–6Published online: November 25, 2015
- Shanthi Srinivasan
Cited in Scopus: 4
Gastroparesis is a clinical condition associated with delayed gastric emptying in the absence of mechanical obstruction. Patients present with nausea, vomiting, bloating, and early satiety. The underlying cause may be related to diabetes but also can be caused by upper gastrointestinal surgery, neurologic disease, collagen vascular disease, viral infections, and drugs.¹ In approximately 35% of patients there is no underlying cause. The pathogenesis and underlying cellular changes in diabetic gastroparesis are largely unknown.