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Basic and Translational Advances in Intestinal and Pancreatic Disease

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Original Research
Open Access
Functional Characterization of Inflammatory Bowel Disease–Associated Gut Dysbiosis in Gnotobiotic Mice
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 4p468–481Published online: March 2, 2016
- Hiroko Nagao-Kitamoto
- Andrew B. Shreiner
- Merritt G. Gillilland III
- Sho Kitamoto
- Chiharu Ishii
- Akiyoshi Hirayama
- and others
Cited in Scopus: 143
Gut dysbiosis is closely involved in the pathogenesis of inflammatory bowel disease (IBD). However, it remains unclear whether IBD-associated gut dysbiosis contributes to disease pathogenesis or is merely secondary to intestinal inflammation. We established a humanized gnotobiotic (hGB) mouse system to assess the functional role of gut dysbiosis associated with 2 types of IBD: Crohn's disease (CD) and ulcerative colitis (UC).