Skip to Main Content

Basic and Translational Advances in Intestinal and Pancreatic Disease

1 Results

Original Research
Open Access
Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 1p92–109Published online: October 22, 2015
- Benjamin N. Rollo
- Dongcheng Zhang
- Lincon A. Stamp
- Trevelyan R. Menheniott
- Lefteris Stathopoulos
- Mark Denham
- and others
Cited in Scopus: 31
Hirschsprung disease (HSCR) is caused by failure of cells derived from the neural crest (NC) to colonize the distal bowel in early embryogenesis, resulting in absence of the enteric nervous system (ENS) and failure of intestinal transit postnatally. Treatment is by distal bowel resection, but neural cell replacement may be an alternative. We tested whether aneuronal (aganglionic) colon tissue from patients may be colonized by autologous ENS-derived cells.