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High-Impact Basic Research

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Original Research
Open Access
Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 4p709–728Published online: February 1, 2019
- Yun Han Kwon
- Huaqing Wang
- Emmanuel Denou
- Jean-Eric Ghia
- Laura Rossi
- Michelle E. Fontes
- and others
Cited in Scopus: 94
Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence suggests the importance of gut microbiota in intestinal inflammation. Considering the close proximity of EC cells and the microbes, we investigated the influence of gut-derived 5-HT on the microbiota and the susceptibility to colitis.