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High-Impact Basic Research

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Original Research
Open Access
Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 1p197–209Published online: September 15, 2018
- Rosa Martin-Mateos
- Thiago M. De Assuncao
- Juan Pablo Arab
- Nidhi Jalan-Sakrikar
- Usman Yaqoob
- Thomas Greuter
- and others
Cited in Scopus: 38
Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators after liver injury. The aim of this study was to analyze the epigenetic modulators that differentially control TGF-β and PDGF signaling pathways.