The GI Research Revolution - A Look Back at 2015

Dear colleagues,

I have had the opportunity to speak to many of you about Cellular and Molecular Gastroenterology and Hepatology. In these conversations you have expressed nearly universal enthusiasm for a rigorous basic and translational science journal focused on biology of the gastrointestinal tract including the liver and pancreas. While there is still a long way to go, the Associate Editors, Becky Wells and Jim Goldenring, and I believe we have made a strong start towards accomplishing this goal. We have included some of the most interesting articles of 2015 in this mini-issue. We hope you enjoy them and would like to hear from you if you have suggestions, concerns, or even criticisms regarding the Journal’s progress.

The articles included in this special year-in-review issue are representative to those we have published throughout the year. They include both a comprehensive review of Barrett’s metaplasia and an original article looking at transcriptional regulation in cancers arising within Barrett’s esophagus. Original studies related to intestinal disease include identification of germline mutations that lead to protein losing enteropathy and an associated editorial, as well as a report describing a new role for the neuromodulator substance P in regulating cytokine production in inflammatory cytokine production in inflammatory bowel disease. There is also a study of enteric neuronal subtypes in a mouse model of Hirchsprung’s disease with an accompanying editorial. The final paper included in this collection identifies alterations in bile production and lipid homeostasis following circadian disruption. In addition to being outstanding examples of the rigorous science you will find within each issue, these articles demonstrate the range of topics we see as within the scope of CMGH.

Read More



Original Research