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Basic and Translational Advances in Epithelial and Stem Cell Biology

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Original Research
Open Access
LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 5p648–662.e8Published online: June 22, 2016
- Yu-Hwai Tsai
- David R. Hill
- Namit Kumar
- Sha Huang
- Alana M. Chin
- Briana R. Dye
- and others
Cited in Scopus: 17
The Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors for R-spondin proteins (Rspo 1, 2, 3, 4), and potentiate Wnt signaling in different contexts. Lgr5 is arguably the best characterized of the Lgr family members in a number of adult and embryonic contexts in mice. However, the function of LGR family members in early embryonic development is unclear, and has not been explored during human development or tissue differentiation in detail.