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Basic and Translational Advances in Epithelial and Stem Cell Biology

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Original Research
Open Access
A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 6p750–766Published online: July 4, 2016
- Jonathan P. Jacobs
- Maryam Goudarzi
- Namita Singh
- Maomeng Tong
- Ian H. McHardy
- Paul Ruegger
- and others
Cited in Scopus: 119
Microbes may increase susceptibility to inflammatory bowel disease (IBD) by producing bioactive metabolites that affect immune activity and epithelial function. We undertook a family based study to identify microbial and metabolic features of IBD that may represent a predisease risk state when found in healthy first-degree relatives.