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Basic and Translational Advances in Epithelial and Stem Cell Biology

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Original Research
Open Access
Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids
Cellular and Molecular Gastroenterology and Hepatology
Vol. 2Issue 1p48–62.e3Published online: October 14, 2015
- Julie In
- Jennifer Foulke-Abel
- Nicholas C. Zachos
- Anne-Marie Hansen
- James B. Kaper
- Harris D. Bernstein
- and others
Cited in Scopus: 161
Enterohemorrhagic Escherichia coli (EHEC) causes over 70,000 episodes of foodborne diarrhea annually in the United States. The early sequence of events that precede life-threatening hemorrhagic colitis and hemolytic uremic syndrome is not fully understood due to the initial asymptomatic phase of the disease and the lack of a suitable animal model. We determined the initial molecular events in the interaction between EHEC and human colonic epithelium.