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Enteric Nervous System and GI Motility

2 Results

Review
Open Access
Neuropods
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 4p739–747Published online: January 30, 2019
- Rodger A. Liddle
Cited in Scopus: 31
Enteroendocrine cells (EECs) are sensory cells of the gastrointestinal tract. Most EECs reside in the mucosal lining of the stomach or intestine and sense food in the gut lumen. Food signals stimulate the release of hormones into the paracellular space where they either act locally or are taken up into the blood and circulate to distant organs. It recently was recognized that many EECs possess basal processes known as neuropods that not only contain hormones but also connect to nerves. This review describes how neuropods contribute to EEC function beyond typical hormonal actions.
Original Research
Open Access
Acinar Cell Production of Leukotriene B₄ Contributes to Development of Neurogenic Pancreatitis in Mice
Cellular and Molecular Gastroenterology and Hepatology
Vol. 1Issue 1p75–86Published online: November 25, 2014
- Rafiq A. Shahid
- Steven R. Vigna
- Amanda C. Layne
- Joelle M.-J. Romac
- Rodger A. Liddle
Cited in Scopus: 9
In the pancreas, activation of primary sensory nerves through the transient receptor potential vanilloid-1 (TRPV1) ion channel contributes to the early stages of development of pancreatitis. Little is known about the mechanism by which this occurs. We investigated whether leukotriene B₄ (LTB₄) is an endogenous agonist of TRPV1 and mediates pancreatitis.