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Cellular and Molecular Gastroenterology and Hepatology
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  • Original Research
    Open Access

    Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

    Cellular and Molecular Gastroenterology and Hepatology
    Vol. 2Issue 4p454–467Published online: April 23, 2016
    • Kyoung Moo Choi
    • Simon J. Gibbons
    • Lei Sha
    • Arthur Beyder
    • Pieter-Jan Verhulst
    • Gianluca Cipriani
    • and others
    Cited in Scopus: 20
      Gastroparesis is a complication of diabetes characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and induces expression of heme oxygenase 1 (HO1) protein. We investigated whether IL10 administration could improve gastric emptying and reverse the associated cellular and electrical abnormalities in diabetic mice.
      Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

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