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Enteric Nervous System and GI Motility

1 Results

Original Research
Open Access
Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System
Cellular and Molecular Gastroenterology and Hepatology
Vol. 5Issue 1p31–49Published online: October 13, 2017
- Emilie Duchalais
- Christophe Guilluy
- Steven Nedellec
- Melissa Touvron
- Anne Bessard
- Yann Touchefeu
- and others
Cited in Scopus: 25
- Video
In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells. However, in the colorectal cancer microenvironment, the most abundant nervous structures belong to the nonmyelinated intrinsic enteric nervous system (ENS). In this study, we investigated whether colon cancer cells interact with the ENS.