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Enteric Nervous System and GI Motility

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Research Letter
Open Access
Age-Related Changes in Gut Microbiota Alter Phenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 1p243–245.e2Published online: September 17, 2018
- Laren Becker
- Estelle T. Spear
- Sidhartha R. Sinha
- Yeneneh Haileselassie
- Aida Habtezion
Cited in Scopus: 14
Macrophages are classified as proinflammatory M1 (classically activated) or anti-inflammatory M2 (alternatively activated),¹ but binary classification fails to distinguish macrophage expression profiles.² Tissue resident muscularis macrophages (MMs) in the gut muscularis externa modulate gut homeostasis including neuromuscular function.^3,4 Through neuroimmune cross-talk, MMs may sense cues in the microenvironment from the microbiota or extrinsic sympathetic neurons and relay this information to enteric neurons.