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Enteric Nervous System and GI Motility

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Original Research
Open Access
Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents
Cellular and Molecular Gastroenterology and Hepatology
Vol. 7Issue 1p185–196Published online: September 20, 2018
- Nicolas Esquerre
- Lilian Basso
- Caroline Dubuquoy
- Madjid Djouina
- Daniel Chappard
- Catherine Blanpied
- and others
Cited in Scopus: 16
Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. We investigated the effects of aluminum ingestion in rodent models of visceral hypersensitivity, and the mechanisms involved.