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2017: Highlights

1 Results

Original Research
Open Access
Interferon-Alpha Promotes Th1 Response and Epithelial Apoptosis via Inflammasome Activation in Human Intestinal Mucosa
Cellular and Molecular Gastroenterology and Hepatology
Vol. 3Issue 1p72–81Published online: September 20, 2016
- Anne Jarry
- Florent Malard
- Chantal Bou-Hanna
- Guillaume Meurette
- Mohamad Mohty
- Jean-François Mosnier
- and others
Cited in Scopus: 25
Several lines of investigation suggest that interferon (IFN) alpha can alter human intestinal mucosa homeostasis. These include the endogenous production of IFN alpha in celiac disease or inflammatory bowel diseases, as well as the occurrence of intestinal side effects of exogenous IFN alpha used as a therapeutic tool. Here, we present an ex vivo translational approach to investigate the effects of IFN alpha on the human normal intestinal mucosa, as well as its underlying mechanisms.