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2017: Highlights

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Review
Open Access
Bacterial Autophagy: Offense and Defense at the Host–Pathogen Interface
Cellular and Molecular Gastroenterology and Hepatology
Vol. 4Issue 2p237–243Published online: May 6, 2017
- James E. Casanova
Cited in Scopus: 36
Autophagy is a fundamental cellular process used for the turnover and recycling of cytosolic components and damaged organelles. Originally characterized as a response to cellular stress, it now is well established that autophagy also is used as a defensive mechanism to combat the infection of host cells by intracellular pathogens. However, although this defensive strategy does limit the proliferation of most pathogens within their host cells, successful pathogens have evolved countermeasures that subvert or circumvent the autophagic response.