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Grant Support: This study was supported by the Research Grafts Council of University Grants Committee of Hong Kong (C7021-21G, T12-703/19-R, 17124219, 17106921).
Disclosures: The authors have no conflict of interest to disclose.
Author Contributions: Study concept and design: Kwan Man, Jiang Liu; Literature search and review: Jiang Liu; Drafting of the manuscript: Jiang Liu; Critical revision: Kwan Man.
Hepatic ischemia/reperfusion injury post liver transplantation is characterized as spatio-temporal microenvironmental disturbance including microcirculatory dysfunction, metabolic dysregulation, oxidative stress, innate and adaptive immunologic response and cell death signaling. The mechanistic understanding enables novel biomarkers and therapeutics development in preclinical models and clinical trials.
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