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DUCTULAR REACTION AND LIVER REGENERATION: FULFILLING THE PROPHECY OF PROMETHEUS!

  • Satdarshan P. Monga
    Correspondence
    Corresponding Author: Satdarshan P. Monga, M.D., FAASLD. Professor of Pathology and Medicine, Director, Pittsburgh Liver Research Center, University of Pittsburgh, School of Medicine and UPMC, 200 Lothrop Street S-422 BST, Pittsburgh, PA 15261 Tel: (412) 648-9966; Fax: (412) 648-1916;
    Affiliations
    Division of Experimental Pathology, Department of Pathology, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, and Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh School of Medicine, Pittsburgh, PA USA
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  • Kari Nejak-Bowen
    Affiliations
    Division of Experimental Pathology, Department of Pathology, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, and Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh School of Medicine, Pittsburgh, PA USA
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Open AccessPublished:November 23, 2022DOI:https://doi.org/10.1016/j.jcmgh.2022.11.007
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      Many acute and chronic liver injuries exhibit histologically as proliferating cholangiocytes, commonly referred to as ductular reaction. The origin of the cells comprising the ductular reaction is dependent on the injury (hepatocyte versus cholangiocyte) as well as capability of these two-liver epithelial or ‘hepithelial’ cells to divide and replace injured cells. What is the role of ductular reaction in hepatobiliary injury versus repair remains debated. While ductular reaction has been shown to be source of pro-inflammatory and profibrogenic factors, it has also been shown to contribute towards maintaining hepatobiliary function during injury. In fact, reducing ductular reaction has been shown to exacerbate while promoting it could alleviate liver injury. We discuss some of the studies that highlight various mechanisms through which ductular reaction plays a beneficial role in modulating hepatobiliary health during injury and eventually discuss how regulating such process may have a therapeutic benefit.

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