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Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis

  • Author Footnotes
    ∗ These authors share senior authorship.
    Keisaku Sato
    Correspondence
    Address correspondence to: Keisaku Sato, Ph.D. Indiana Center for Liver Research, Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle RO 009, Indianapolis IN 46202, USATel: +1 317 278 4227
    Footnotes
    ∗ These authors share senior authorship.
    Affiliations
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
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  • Linh Pham
    Affiliations
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

    Department of Science and Mathematics, Texas A&M University – Central Texas, Killeen, TX;
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  • Shannon Glaser
    Affiliations
    Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX;
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  • Heather Francis
    Affiliations
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

    Richard L. Roudebush VA Medical Center, Indianapolis, IN
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  • Author Footnotes
    ∗ These authors share senior authorship.
    Gianfranco Alpini
    Footnotes
    ∗ These authors share senior authorship.
    Affiliations
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

    Richard L. Roudebush VA Medical Center, Indianapolis, IN
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  • Author Footnotes
    ∗ These authors share senior authorship.
Open AccessPublished:November 23, 2022DOI:https://doi.org/10.1016/j.jcmgh.2022.11.006
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      Keywords

      Abbreviation:

      CK (cytokeratin), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), HPCs (hepatic progenitor cells), HSCs (hepatic stellate cells), IL (interleukin), NAFLD (non-alcoholic fatty liver disease), PSC (primary sclerosing cholangitis), SASP (senescence-associated secretory phenotype), TGF (transforming growth factor)

      Linked Article

      • DUCTULAR REACTION AND LIVER REGENERATION: FULFILLING THE PROPHECY OF PROMETHEUS!
        Cellular and Molecular Gastroenterology and Hepatology
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          Many acute and chronic liver injuries exhibit histologically as proliferating cholangiocytes, commonly referred to as ductular reaction. The origin of the cells comprising the ductular reaction is dependent on the injury (hepatocyte versus cholangiocyte) as well as capability of these two-liver epithelial or ‘hepithelial’ cells to divide and replace injured cells. What is the role of ductular reaction in hepatobiliary injury versus repair remains debated. While ductular reaction has been shown to be source of pro-inflammatory and profibrogenic factors, it has also been shown to contribute towards maintaining hepatobiliary function during injury.
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