Abbreviation:CK (cytokeratin), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), HPCs (hepatic progenitor cells), HSCs (hepatic stellate cells), IL (interleukin), NAFLD (non-alcoholic fatty liver disease), PSC (primary sclerosing cholangitis), SASP (senescence-associated secretory phenotype), TGF (transforming growth factor)
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This work was supported by the Hickam Endowed Chair, Gastroenterology, Medicine, Indiana University, the Indiana University Health – Indiana University School of Medicine Strategic Research Initiative, the Senior Career Scientist Award (IK6BX004601) and the VA Merit award (5I01BX000574) to GA and the Career Scientist Award (IK6BX005226) and the VA Merit award (1I01BX003031) to HF from the United States Department of Veteran’s Affairs, Biomedical Laboratory Research and Development Service and NIH grants DK108959 and DK119421 (HF), DK054811, DK115184, DK076898, DK107310, DK110035, DK062975 and AA028711 (GA and SG), the PSC Partners Seeking a Cure (GA). Portions of these studies were supported by resources at Richard L. Roudebush VA Medical Center, Indianapolis, IN, and Medical Physiology, Medical Research Building, Temple, TX. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
Conflict of interest: The authors have no conflict of interest to declare.
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