BACKGROUND & AIMS
Abbreviations used in this paper:BMI (body mass index), [Ca2+]i (intracellular calcium), FAS (fatty acid synthase), GPCRs (G protein-coupled receptors), GLP-1 (glucagon-like pepetide-1), GPR120 (G protein coupled receptor 120), GPR40 (G protein coupled receptor 40), HFD (High-fat diet), IPGTT (intraperitoneal glucose tolerance test), LA (Linoleic acid), LCFA (long-chain fatty acid), OA (oleic acid), PPAR-γ (peroxisome proliferator-activated receptor-γ), SCD1 (stearoyl-CoA desaturase-1), SREBP1c (sterol-regulatory element-binding transcription factor 1c), SSO (sulfo-N-succinimidyl oleate), TBC (taste bud cells)
Publication stageIn Press Journal Pre-Proof
Grant support: This study was supported by a financial support from the SATT (Société d'Accélération du Transfert de Technologies) Grand-Est (Dijon) that financed two projects (ImmorTasteCell and FaTasteAnalogues). This project was also supported by the University of Burgundy as BQR (bonus-qualité-recherche). The DRRT (délégation régionale à la recherche et à la technologie) at Dijon granted a project on the synthesis of fat taste agonists. The BFC (Burgundy Franche Comté) Région also granted a post-doc scholarship to one of the authors (MS). The BFC (Burgundy Franche Comté) Région also sanctioned a project “Tasty Lipids” in the category “Envergeure” that helped realize a large of research work. A grant for the recruitment of a technician is also acknowledged from LipStick Excellence laboratory (ANR-11-LABX-0021-LipSTIC). SY was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 796245 and the NATO SPS grant No. 985291. The computations were performed using HPC resources from the Centre de Calcul Régional Romeo and the Mésocentre de Calcul de Franche-Comté.
Disclosures: The authors have nothing to disclose and there was no conflict of interest among them.
Data transparency statement: The original data will be made available upon a reasonable request.
Acknowledgements: We sincerely acknowledge the technical assistance of Miss Charmaine Bastian Joseph, Miss Anoucheka Bories and Mr Anthony-Damien Desirée.
Two high affinity agonists of tongue taste receptors (CD36/GPR120) were synthesized. They acted as fat taste enhancers and triggered the activation of tongue-gut satiation loop in male mice. These agents decreased daily fat-rich food intake and body weight gain in diet-induced obese male mice.
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