Background & Aims
List of abbreviations:ALT (alanine aminotransferase), AST (aspartate aminotransferase), BM (Bone marrow-derived), Cit-H3 (citrullinated histone-3), DC (dendritic cells), ERK (extracellular regulated protein kinases), FGL2 (fibrinogen-like protein 2), FH (fulminant hepatitis), FVH (fulminant viral hepatitis), HBV (hepatitis B virus), HC (healthy control), MAPK (mitogen-activated protein kinases), MCOLN3 (mucolipin3), MHV-3 (murine hepatitis virus strain-3), MPO (myeloperoxidase), NE (neutrophil elastase), NETs (neutrophil extracellular traps), NK (natural killer cell), PAD4 (peptidyl arginine deiminase type IV), PCA (procoagulant activity), pDC (plasma dendritic cells), RNA-Seq (RNA sequencing), Treg (regulatory T cell)
Publication stageIn Press Journal Pre-Proof
This work was supported by the National Key Research and Development Program of China (2021YFC2600200), the National Natural Science Foundation of China (NO. 81974075), the National Youth Talent Support Program (NO. 0106540082), Wuhan Science and Technology Bureau (2020020601012236), Natural Science Foundation of Hubei Province (2020CFB767) and Youth Science Foundation of Tongji Hospital (2020YQ014).
Disclosures: The authors declare no conflict or competing interests.
Authors contributions: Xiaojing Wang and Qin Ning designed the project. Xiaoping Luo provided key interactive information and discussion. Junjian Hu helped in designing animal experiments. Qiang Gao, Wenhui Wu and Suping Hai collected clinical data. Xitang Li performed most of the experiments and analyzed data with the assistance of Qiang Gao, Wenhui Wu, Suping Hai, Junjian Hu and Jie You. Jie You, Da Huang, Hongwu Wang, Dong Xi, Weiming Yan and Tao Chen participated in the data discussion and provided suggestions. Meifang Han and Di Wu provided essential materials. Xitang Li wrote the manuscript. Xiaojing Wang, Xiaoping Luo and Qin Ning helped revise the manuscript.
We thank the members of Institute of infectious diseases of Tongji Hospital for their pertinent advice, and also thank Dr. Cailing Chen from the department of otolaryngology-head and neck surgery of Tongji Hospital for her kindly suggestions.
Data availability：All data in our study are available upon request.
Synopsis: We clarified that increased NETs formation was observed in fulminant viral hepatitis (FVH), but not in acetaminophen-treated mice. NETs depletion improved the survival rate in FVH by inhibiting fibrin deposition and inflammation. In depth, NETs formation was modulated by FGL2-MCOLN3-autophagy-axis.
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