ABSTRACT
Background & Aims
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Results
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List of Abbreviations:
Acaa1 (acetyl-CoA acyltransferase 1), Acly (ATP-citrate lyase), Acox1 (acyl-CoA oxidase 1), BrdU (5-Bromo-2'-deoxyuridine), CD36 (cluster of differentiation 36), CHOL (cholesterol), Cytb (cytochrome B), Dgat1 (diacylglycerol acyltransferase 1), Elovl5/6 (elongation of very long-chain fatty acids protein 5/6), FABP4 (fatty acid-binding protein 4), Fasn (fatty acid synthase), FA (fatty acid), FoxO1 (forkhead box O 1), GluCer (glucosylceramide), GPL (glycerophospholipids), Hadh (hydroxyacyl-CoA dehydrogenase), HDL-c (high-density lipoprotein cholesterol), Hmgcl (hydroxymethylglutaryl-CoA lyase), Hmgcs2 (hydroxymethylglutaryl-CoA synthase), LDL-c (low-density lipoprotein cholesterol), mTORC2 (mammalian target of rapamycin complex 2), MTTP (microsomal triglyceride transfer protein), PCNA (proliferating cell nuclear antigen), PFT-α (pifithrin-α), PH (partial hepatectomy), PPAR-α (peroxisome proliferator-activated receptor α), R-LKO (liver-specific knockout Rictor), Scl27a2 and Scl27a5 (solute carrier family 27 member 2 and 5), SP (sphingolipids), SPT (serine palmitoyltransferase), SREBP1c (sterol regulatory element-binding transcription factor 1c), VLFA (very long-chain fatty acids), TG (triglyceride)Article Info
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Financial Support: This study was supported by the National Natural Science Foundation of China (92049304, 81801372, 91949125, 82171545, 82030039), National Key R&D Program of China (2021YFA0804903), Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2017ZT07S347), and Innovative Team Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110103002).
Authorship notes: Lingling Zhang, Yanqiu Li, Ying Wang, and Yugang Qiu contributed equally to this work.
Disclosures: All authors declare no potential conflicts of interest (financial, professional, or personal).
Writing Assistance: supported by the National Natural Science Foundation of China (91949125).
Author contributions: Lingling Zhang, Zhenyu Ju, and Leiming Liu designed the experiments; Yanqiu Li, Ying Wang, and Yugang Qiu performed the western blot and IHC staining experiments; Lingling Zhang and Ying Wang performed the PH experiments; Jiyuan Yao and Hanchuan Mou identified the genetic background of the mice and performed the RT-qPCR experiments; Jirong Wang, Zhouxin Yang, GenXiang Mao, Jiyuan Yao, and Zhongjie Lu were responsible for maintenance of the experimental mice; Zhiqing Xia, Wenzhe Zhang, Di Zhu, Leimin Sun, and Dan Chen performed the chemical index tests; Lingling Zhang, Ying Wang, and Leiming Liu wrote the manuscript.
Data Transparency statement: All data, analytic methods, and study materials have been made available in the results, figures, and materials and methods of this article.
SYNOPSIS
Fatty acids are mainly transported into hepatocytes during liver regeneration, mTORC2 facilitates fatty acids oxidation through the GluCer-PPAR-α pathway，thereby establishing its novel role in lipid metabolism (Graphical Abstracts).
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